Previewing the Exciting Matchups in the Week NFL Schedule

for five more scores He was also intercepted 10 times and sacked 16 times However, if Watson can’t go, backup Case Keenum has faced the Colts twice as a member of the Denver Broncos, completing 67% of his passes for 437 yards, three touchdowns, and two interceptions — Jake Trotter

Bold prediction: Browns WR Jarvis Landry will have his first 100-yard receiving game of the season. Landry has been a consistent target for the Browns, but has yet to have a breakout game. Facing a Colts defense that ranks 22nd in pass defense, Landry has a good opportunity to have a big performance — Eric Williams

Stat to know: The Colts’ defense has allowed the fewest rushing touchdowns in the NFL this season with only two. The Browns, on the other hand, have the second-most rushing touchdowns in the league with 12. Something has to give in this matchup between strength vs. strength — Seth Walder

Matchup X factor: Colts QB Carson Wentz. The Browns have struggled against quarterbacks who can extend plays with their legs, and Wentz has shown the ability to do just that. If Wentz can make plays with his legs and keep the Browns’ defense off balance, it could be a long day for Cleveland — Jake Trotter

Injuries: Browns: CB Greg Newsome II (hip) is questionable; Colts: TE Mo Alie-Cox (knee) is questionable

What to know for fantasy: Browns RB Nick Chubb has scored a touchdown in every game he’s played this season, but the Colts’ defense has allowed the fewest rushing touchdowns in the league. Chubb could be in for a tough matchup — Eric Moody

Betting nugget: The Browns are 5-1-1 ATS in their past seven games as road favorites. Read more.

Moody’s pick: Browns 24, Colts 20
Walder’s pick: Browns 27, Colts 21
FPI prediction: CLE by an average of 4.1 points

Matchup must-reads: Browns’ run game finds success by ‘passing’ the torch … Colts’ record doesn’t reflect the fights left in the team … Will Carson Wentz’s COVID-19 status impact the outcome against the Browns?

Bills – at Patriots – 1 p.m. ET, CBS
Spread: BUF -3

Storyline to watch: The Patriots are coming off a bye week and have won four straight games after starting the season 2-4. They have found their groove on offense behind rookie QB Mac Jones and a strong rushing attack. The Bills’ defense, on the other hand, has struggled in recent weeks and will need to step up to contain the Patriots’ balanced offensive attack — Marcel Louis-Jacques

Bold prediction: Patriots RB Damien Harris will rush for over 100 yards and two touchdowns. The Bills’ defense has been vulnerable against the run, allowing the third-most rushing yards per game in the league. Harris has been productive this season and should have a big game against Buffalo — Mike Reiss

Stat to know: The two teams have split their past 10 meetings, with the home team winning each matchup. The Patriots have won the past two meetings at home against the Bills by a combined score of 76-6 — Seth Walder

Matchup X factor: Bills WR Stefon Diggs. The Patriots’ defense has been excellent this season, but they have struggled at times against elite wide receivers. Diggs is one of the best in the league and could have a big game if he can find success against New England’s secondary — Marcel Louis-Jacques

Injuries: Bills: WR Emmanuel Sanders (knee) is questionable; Patriots: WR Nelson Agholor (concussion) is questionable, TE Jonnu Smith (shoulder) is questionable

What to know for fantasy: Patriots RB Ramon Humber Stevenson has scored a touchdown in four straight games and could be in line for another productive outing against a Bills’ defense that has struggled against the run recently — Eric Moody

Betting nugget: The Bills have covered the spread in five of their past six games against AFC East opponents. Read more.

Moody’s pick: Patriots 27, Bills 24
Walder’s pick: Bills 24, Patriots 21
FPI prediction: BUF by an average of 1.6 points

Matchup must-reads: Top seed still possible for Bills after MNF mess … Is Mac Jones morphing into a young Tom Brady? … The return of Josh Allen: Inside the preparation for January temps … How the Patriots have turned around their season.